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Structure

Andrographolide 5508-58-7

Andrographolide 5508-58-7

Specifications

  • Catalogue No.: 35986
  • Product Name: Andrographolide
  • CAS: 5508-58-7
  • EC: 226-852-5
  • MDL: MFCD07778082
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  • Price: $900/1kg
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Properties

Assay: 99%
Appearance: powder
Pptical activity [α]20/D -126°, c=1.5 in acetic acid
Mp: 229-232℃

Andrographolide 5508-58-7 is a bicyclic diterpenoid lactone displaying antiviral, antiinflammatory, antiapoptotic, and antihyperglycemic properties. This chemical is an irreversible antagonist of NF-κB and prevents in vitro T cell activation. Andrographolide displays no effect on IκBa degradation but downregulates iNOS and Mac-1 expressions and ROS production. It has been shown to prevent endotoxin shock in mouse models and is reported to activate PI 3K/Akt pathways. Andrographolide is also an inhibitor of ERK.

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